Cisplatin atherosclerosis
WebJul 1, 2024 · Atherosclerosis is a specific type of arteriosclerosis. Atherosclerosis is the buildup of fats, cholesterol and other substances in and on the artery walls. This buildup is called plaque. The plaque can … WebOct 31, 2024 · It has been found that cisplatin may induce DNA damage and cancer cell death also by induction of oxidative stress, particularly the overproduction of mitochondrial reactive oxygen species (ROS) and by decreasing the pool of intracellular antioxidants, e.g. reduced glutathione (GSH).
Cisplatin atherosclerosis
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WebJul 1, 2016 · Nephrotoxicity is a well documented adverse effect of cisplatin use, with a dose-dependent and irreversible reduction in renal function. 75, 76, 77 Possible mechanisms include endothelial and epithelial cell damage and dysfunction. 78 Patients treated with cisplatin-based chemotherapy have a high prevalence of microalbuminuria … WebNational Center for Biotechnology Information
WebJun 27, 2014 · A 52-year-old executive was referred to our clinic for risk factor management after undergoing coronary computed tomography angiography (CTA) as part of an … WebRecently, a genome-wide analysis of cisplatin-induced peripheral neuropathy in survivors of adult-onset cancer reported that genetically determined expression level of RPRD1B …
WebTherefore, selective inhibition of CaMKIIγ in lesional macrophages holds great promise for the treatment of advanced atherosclerosis. We recently developed a siRNA NP platform that can selectively silence CaMKIIγ in macrophages, resulting in increased plaque stability. WebAug 14, 2024 · Lipopolysaccharide (LPS) is an endotoxin that induces systemic inflammatory responses. Melittin, a main constituent of bee venom, exerts several biological activities such as antioxidant, anti-inflammatory, and antiapoptotic actions. However, whether melittin protects against endotoxin-induced AKI remains undetermined.
WebDec 30, 2024 · However, cardiovascular toxicity is a major concern. In addition to acute endothelial toxicity and associated risk of arterial thrombosis, accelerated atherosclerosis may be the result of chemotherapy-associated latent cardio-metabolic dysfunction. A 45-year-old man began treatment with cisplatin-based chemotherapy for testicular cancer.
WebNov 5, 2024 · Since its introduction in the late 1970s, cisplatin-based chemotherapy (CBCT) has revolutionized the treatment of metastatic testicular cancer (TC) and … burwood council nswWeb2 days ago · Radiation therapy (RT) significantly increased the incidence of coronary artery diseases, especially atherosclerosis. Endothelial dysfunction has been the major side effect of RT among tumor patients who received RT. However, the involvement between endothelial dysfunction and radiation-induced atherosclerosis (RIA) remains unclear. ham rong bridgeWebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … burwood dcj officeWebDec 16, 2024 · Introduction: Cisplatin-based chemotherapeutic regimen (CBCR) is known for increasing risk of venous thromboembolic (TE) disease. We report a unique case of STEMI associated with CBCR which we believe was caused by coronary artery … burwood events cinema session timesWebCisplatin causes direct and acute endothelial toxicity with a propensity to arterial thrombosis, irrespective of the presence of underlying atherosclerosis.7 Any longer … burwood district bowling clubWebAcute clinical syndromes associated with cisplatin infusion include chest pain, palpitations, and, occasionally, elevated cardiac enzymes indicative of myocardial … ham roll ups with cream cheese and picklesWebOct 6, 2024 · The potential exists to alter the course of atherosclerosis with anti-inflammatory drugs. With increased understanding of the specific mechanisms that … burwood doctors surgery thatcham