2024 Cyclophosphamide induced cardiotoxicity

Cyclophosphamide induced cardiotoxicity

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August undefined, 2024

WebJun 22, 2024 · Cyclophosphamide (CP) is a widely used chemotherapeutic agent but its clinical usefulness is challenged with different forms of toxicities. No studies have evaluated the possible protective effect of nicorandil (NIC) in CP-induced cardiotoxicity. WebApr 11, 2024 · Cyclophosphamide (CTX) is an alkylating agent of nitrogen mustard with broad anti-tumor activity, but excessive or prolonged use can result in toxic s…

Cyclophosphamide toxicity. Characterising and avoiding the …

WebDec 1, 2024 · Cyclophosphamide-induced cardiotoxicity involves multiple mechanisms; oxidative stress, apoptosis, myocardial inflammation, endothelial dysfunction, calcium … WebFeb 1, 2024 · CP-induced cardiotoxicity ranges from 7 to 28% and mortality ranges from 11 to 43% at the therapeutic dose of 170-180 mg/kg, i.v. CP undergoes hepatic metabolism that results in the production of aldophosphamide. Aldophosphamide decomposes into … creative depot blog

The Role of Antioxidants in Ameliorating …

WebCardiotoxicity that was thought to be related to CYA occurred in 1/32 (3%) of patients in Group 1 and in 13/52 (25%) patients in Group 2 (P less than 0.025). Congestive heart … WebApr 7, 2024 · This present study investigated the protective effects of asperuloside (ASP) against cadmium-induced nephrocardiac toxicity. Rats were treated with 50 mg/kg of ASP for five weeks and CdCl2 (5 ... WebPossible protective effects of a methanolic extract of Viscum album (VA) and quercetin (QE) against cyclophosphamide (CP) induced cardiotoxicity, urotoxicity and genotoxicity in mice were evaluated. Mice were administered orally VA (250 mg/kg/day) and QE (50 mg/kg/day) for 10 days alone or in combination with CP. creative depot stempel weihnachten

Molecular mechanism involved in cyclophosphamide …

Effect of Cyclophosphamide on the Biosystem Request PDF

WebCardiotoxicity commonly refers to toxicity that has a detrimental impact on the heart, which might finally lead to myocardiopathy such as arrhythmia, myocardial infarction and myocardial hypertrophy. These inevitable side effects, especially of anticancer drugs, are usually the main causes of treatment termination and drug development failure. WebHighly differing rates of cardiac complications associated with high-dose cyclophosphamide have been reported. To date, no systematic clinical study has investigated high-dose cyclophosphamide mobilization regimens in multiple myeloma patients and evaluated its cardiotoxicity. creative cuts easton mdWebFeb 5, 2024 · INTRODUCTION. Cyclophosphamide (CP) is widely used in chemotherapy for malignant tumors and as an immunosuppressant for the prevention of graft rejection and treatment of chronic autoimmune diseases.1 It is one of the most effective and safe drugs used for such diseases.2 However, its detrimental side effects cannot be ignored. Thus, … creative d100 speakers bluetooth fails

"WebJul 14, 2014 · Cyclophosphamide-induced cardiotoxicity (CIC) is a well-known adverse effect and not that uncommon . Symptoms occur usually within 1 to 3 weeks, and … " - Cyclophosphamide induced cardiotoxicity

Cyclophosphamide induced cardiotoxicity

Cardiotoxicity: An Unexpected Consequence of HER2-Targeted …

WebFeb 1, 2024 · Phosphoramide is an active neoplastic agent, and acrolein is a toxic metabolite which acts on the myocardium and endothelial cells. This is the first review … WebApr 12, 2024 · Request PDF On Apr 12, 2024, Sarmad Hayder and others published Effect of Cyclophosphamide on the Biosystem Find, read and cite all the research you need on ResearchGate

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WebMar 24, 2024 · Cyclophosphamide, which can inhibit DNA replication and apoptosis, is a kind of DNA-alkylating agent for breast cancer, cyclophosphamide-induced cardiac damage is dose dependent, and mechanisms of cyclophosphamide-induced cardiotoxicity encompass oxidative and nitrative stress and protein adduct formation. WebCyclophosphamide- and ifosfamide-induced cardiotoxicity is dose dependent and usually presents few days after treatment. High doses (>140 mg/kg) are considered very cardiotoxic.

WebJun 1, 2016 · PDF ABSTRAK Latar belakang: Kemoterapi sering menimbulkan efek samping berupa toksisitas hematologi. Derajat toksisitas yang timbul sering dikaitkan... Find, read and cite all the research you ... WebFeb 7, 2024 · The clinical features of fatal cyclophosphamide-induced cardiotoxicity in a conditioning regimen for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Ann Hematol 2016; 95(7): 1145–1150. Crossref. PubMed. Google Scholar. 35. Duléry R, Mohty R, Labopin M, et al. Early cardiac toxicity associated with post-transplant ...

WebJan 1, 2013 · The precise mechanism of cyclophosphamide-induced cardiac toxicity has not been established. Cyclophosphamide metabolites are believed to cause oxidative … WebJul 14, 2014 · Cyclophosphamide-induced cardiotoxicity was suspected and she was given treatment for congestive heart failure. Her dyspnea decreased and she was discharged on the tenth day with a left ventricular ejection fraction of 37% and normal right ventricular function.

WebJul 18, 2015 · Cardiotoxicity and nephrotoxicity were induced in rats by a single injection of cyclophosphamide (CP; 200 mg·kg −1 , i.p.) on the first day of experimental period, whereas taurine (Tau; 200 mg ...

WebMay 1, 1981 · Cyclophosphamide in this high dose is associated with a toxic, often fatal, pericardiomyopathy. Depression of ECG voltage and systolic left ventricular function, … creative dance and music harveyWebJan 1, 2024 · Administration of Chemotherapeutics, especially doxorubicin (DOX) and cyclophosphamide (CPS), is commonly associated with adverse effects such as myelosuppression and cardiotoxicity. At this... creative design agency manchesterWebMay 11, 2024 · Though mechanism of cyclophosphamide-induced cardiotoxicity is not completely understood, it is thought to encompass oxidative and nitrative stress. As such, this review focuses on antioxidants... creative dance belchertownWebSep 15, 2024 · Cardiotoxicity is divided into four categories: 1) directed cytotoxic effects of chemotherapy and associated cardiac dysfunction (including alkylating agents, … creative data systems incWebOct 8, 2024 · Our study validates the involvement of oxidative stress in Doxorubicin and Cyclophosphamide-induced cardiotoxicity . Interleukin-converting enzyme (ICE, … creative description of an islandWebCardiotoxicity is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. The mechanism of anthracycline induced cardiotoxicity seems to involve the formation of free radicals leading to oxidative stress. This may cause apoptosis of … Cardiotoxicity of cytotoxic drugs creative d200 wireless speakerWebThe study was designed to evaluate the cardioprotective potential of Saraca indica (SI) herb extract on the basis of biochemical, electrocardiographic and histo creative cuts brunswick ohio